Our prior studies demonstrated that T-helper1 (Th1) type of cellular response was generated by six potential recombinant proteins <i>viz</i>. elongation factor-2 (elF-2), enolase, aldolase, triose phosphate isomerase (TPI), protein disulfide isomerase (PDI) and p45, derived from a soluble antigenic fraction (89.9-97.1 kDa) of <i>Leishmania (Leishmania) donovani</i> promastigote, in treated <i>Leishmania</i> patients and golden hamsters and showed significant prophylactic potential against experimental VL.
In this study, we selected Amastin, CaNA2, Kmp-11 and PDI proteins of Leishmania donovani for study, which are VL vaccine candidates or possible drug targets.
The in vitro as well as in vivo results thus indicate that LdPDI may be exploited as a potential vaccine candidate against visceral Leishmaniasis (VL).